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As this enzyme catalyzes a reversible reaction between isocitrate and -ketoglutarate, the inverse reaction, so called the reductive carboxylation, could occur to maintain TCA cycle intermediates under mitochondria defects

[DOI] [PubMed] [Google Scholar] 244.Guyenet S.J., Furrer S.A., Damian V.M., Baughan T.D., La Spada A.R., Garden G.A

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I think it's one of the more, I would say niche supplements and that the everyday person isn't might not be super aware of glutathione, but in the health and wellness sphere in the biohacking world, everybody knows about glutathione

doi: 10.3201/eid2303.161552 248 WilkinsonT