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The intrinsic fluorescence of Fento-1 revealed its localization at the plasma membrane when experiments were conducted at a low temperature to reduce endocytic flux (Extended Data Fig

It is often associated with multiple genetic polymorphisms including filaggrin mutations, variations in N -acetyltransferases (NATs), glutathione S -transferases (GSTs), cytokine genes (e.g., TNF-, IL-16), and various immune enzymes [9, 38, 39]

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