Lees studies are smaller than most rigorous clinical trials, ranging in size from two to 16 study participants, and dont include comparison groups
Genes downregulated by copper peptide ghk-cu include those linked with swelling (pro-swelling cytokines, swelling signaling), fibrosis and scarring (TGF-beta pathway components), cancer progression (oncogenes, metastasis-related genes), and tissue breakdown (certain proteases)
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Instead, its targeting is due to its binding affinity for Globular Actin within cells