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Although the exact reason for such conflicting results is not clear, specific features of brain energy metabolism (Reference McKenna, Dienel, Sonnewald, Brady, Siegel and Albers48) , concurrent supplementation with other antioxidants or probable technical issues may be involved in producing these results

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They require NAD+ as a cofactor to function

IGF-1 is a hormone growth factor that must bind to an insulin-like growth factor binding protein (IGFBP) to travel from the liver (via the bloodstream) into the brain and individual cells

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