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Early trials in men showed that PT-141 produced penile erections in the absence of external stimulation a finding with significant mechanistic implications, as it demonstrated central-pathway arousal independent of peripheral vascular action

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Neuroinflammation induces neurodegeneration

Expression of these AR circRNAs was upregulated during castration-resistant progression, with levels of AR circRNAs correlated strongly with those of the linear AR transcripts, indicating a transcriptional mechanism of regulation

But others think that, for all its flaws, the FDAs drug approval system is among the best in the world