After Week 8, the frequency of insulin glargine titration was left to the discretion of the investigator, but, at a minimum, the glargine dose was to be revised, if necessary, at Weeks 12 and 18
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As mentioned above, the ability of GLP-1 to regulate cholesterol metabolism and the fact that GLP-1 circulates between the CNS and systemic metabolism suggest that GLP-1 is an important target in the treatment of cerebrovascular diseases in terms of altered cholesterol metabolism and vascular dysfunction
Patients who notice persistent palpitations, particularly if accompanied by chest discomfort or breathlessness, should report these symptoms to their healthcare provider
Hence the similar effects of SGLT2-inhibitors, despite a completely different mechanism of action