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In the epidermis of vitiligo lesions, a marked decrease in the expression of c-kit, the stem cell factor receptor, and the MITF transcription factor (microphthalmia-associated transcription factor) has been detected, along with a reduction in endothelin B receptor.40 A marked reduction in microRNA-211 expression has also been observed, associated with a lower oxygen consumption rate, aberrant mitochondrial complexes, alterations in lipid metabolism, and an increase in reactive oxygen species

Truth Signs and Symptoms of a B12 Deficiency: Fatigue or weakness Brain fog or memory problems Tingling in hands and feet (neuropathy) Mood changes, irritability, or depression Pale or jaundiced skin Glossitis (a swollen, inflamed tongue) Dizziness or shortness of breath Visual disturbances If youve been dealing with any combination of these symptoms, its worth looking into your B12 status

Funding Natural Science Foundation of Inner Mongolia Autonomous Region Project 2022MS08039.Baotou Medical College Research and Innovation Programme BYKYCX202405

Magson NR, et al