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Dual glucagon like peptide 1 (GLP1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists are among the new pharmacological strategies recently developed to address this challenge

At week 52, using the treatment-policy estimand analysis, however, the oral semaglutide group experienced significantly greater decreases in A1C compared with both the liraglutide and placebo groups

B CV outcomes trials (CVOTs) of dipeptidyl peptidase 4 (DPP-4) inhibitors have all, so far, not shown CV benefits relative to placebo

A patient on 15 mg weekly might step down to 10 mg, then 7.5 mg, then 5 mg, then 2.5 mg, each for four weeks before the next reduction

Potent incretin-based therapy for obesity: a systematic review and meta-analysis of the efficacy of semaglutide and tirzepatide on body weight and waist circumference, and safety