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Activation of this pathway has been associated with the promotion of cell survival, inhibition of apoptosis, and a reduction in neuroinflammation [227]

On the other hand, in a study in conscious dogs during double blockade of the RAS (combined ACE inhibition and aldosterone receptor blockade), Ang III was significantly more potent than Ang II in increasing aldosterone release 55, 109 and also produced a very potent antinatriuretic effect already at a dose not producing an increase in blood pressure