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doi: 10.1080/01635581.2020.1779321 338 ZhangZ-LHoSCLiuK-YMoX-FFengX-LLiLet al

Gradual dose reduction allows receptor density to adjust incrementally rather than experiencing a sharp signal drop that triggers compensatory suppression

However, if you're experiencing significant side effects, you should hold at your current dose for an additional 2-4 weeks before attempting to increase