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Insulin-like growth factor (IGF-1): Anabolic growth factor promoting cell proliferation, protein synthesis, matrix production in bone and cartilage

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While speculative, early research suggests microbiome composition influences metabolic health outcomes independently and may be modifiable to improve treatment response

GSK3 activation is also associated with oxidative stress and inflammation, both of which have been reported to be elevated in bipolar disorder patients [82,83,84,85]

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