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This slows metabolism, reduces strength, and can make weight regain easier

The enzyme glutathione reductase then regenerates GSH from GSSG using NADPH as a cofactor, maintaining the critical GSH:GSSG ratio that reflects cellular redox status

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Other medications worth flagging include nitroglycerin (glutathione may blunt its vasodilating effect), certain antipsychotics, and long term proton pump inhibitors, which reduce stomach acid and impair absorption of cysteine precursors

For example, a 2020 study combined metabolomics, proteomics and genomics to show that activated T cells use methionine to synthesize SAM, identifying methionine as a key nutritional factor in shaping T helper cell activity through histone methylation (Roy, D