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In the fibrotic context, metabolic pathways driven by specific amino acids directly support cellular proliferation, differentiation, and excessive ECM deposition, which are hallmark features of fibrogenesis

Chronic inflammation is probably the biggest driver, whether from gut infections like SIBO or candida, autoimmune conditions, or persistent immune activation

This "energy sink" literally starves the brain, heart, and skeletal muscles of energy, directly causing the hallmark symptom of post-exertional malaise (PEM) and the severe exercise intolerance seen in these conditions

Xu J, Zhang C, Khanna A