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The Lancet 362(9386):777781 Solomon SD, Vaduganathan M, Claggett BL, Packer M, Zile M, Swedberg K et al (2020) Sacubitril/Valsartan across the spectrum of ejection fraction in heart failure

This is believed to be down to body composition, as women typically have a higher body fat percentage and female-specific hormones, which may interact with the drug differently