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A commenter urged CMS to assess and disclose the cost implications for medical practices, noting their belief that implementing a three mode protocol may introduce new financial and operational burdens, particularly for small and rural practices

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However, GLP-1 agonists are prescription-strength and require medical supervision to manage nausea, constipation, or other effects during dose escalation

Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets