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Both utilized antibiotic depletion (ABX) to diminish the microecological background, verified therapeutic transferability via fecal microbiota transplantation (FMT), and further achieved partial simulation or restoration of therapeutic phenotypes through butyrate/sodium butyrate supplementation (rescue) ( Level B Support: In the CFA-induced RA rat experiment, the study found that after antibiotic (ABX) treatment, the improvement effect of JFG on foot swelling, synovial lesions and inflammatory factors was significantly weakened