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as the first therapy to help people manage their weight and reduce cardiovascular risks, Martin Holst Lange, executive vice president and head of development at Novo Nordisk, told the WSJ

Edema is not an indication, and peripheral edema is not listed among the drug's common adverse reactions

Oxidative stress under shear alters the ability of the cell to deform, changes cell morphology, its orientation in the shear stress field, and appears to alter intracellular and membrane characteristics