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In the glyoxalase pathway, a branch of glycolysis, glucose is converted to methylglyoxal and subsequently processed by glyoxalase 1 (GLO1) and GLO2 into d-lactate and glutathione
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[PubMed] [Google Scholar] 301.Ravn-Haren G
Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue
