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An interim analysis was planned after two thirds of the total events had accrued with clear stopping rules and an alpha spending function to account for this interim look (in fact, the interim analysis did not take place until 741 events, out of the planned 854, took place)

These patients may have visceral adiposity, insulin resistance, or unfavorable lipid profiles despite appearing healthy by BMI standards

Supplementary Table 3)

So, the increased risk of getting breast cancer after using hormone therapy is small for most women, Santoro said

Animal studies report a plasma half-life around 4 hours after intraperitoneal administration