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4.1 Risks of supplement use during chemotherapy The use of natural remedies during chemotherapy in breast cancer is a compound scenario that includes the safety issue as well as drugsupplement interferences and merits meticulous assessment, because these interventionsusually considered as harmless substancesmay significantly alter the pharmacokinetic/pharmacodynamic response, antitumoural activity, and toxicity profile to conventional oncologic treatment (200)
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Materials and methods Drugs Levothyroxine sodium hydrate (LT4) (powder form, pack size: 50 mg, Sigma-Aldrich, MO, USA) and dapagliflozin (DAPA) (5 mg film-coated tablet, AstraZeneca Pharmaceuticals LP, Indiana, USA) were used in this study
Limited clinical data on this specific route for glutathione, though buccal drug delivery is well-established for other compounds
