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Type 1 vs Type 2 Diabetes: A Fundamental Difference Type 2 Diabetes Insulin is still produced (at least initially) There is insulin resistance GLP-1 agonists stimulate insulin secretion (in a glucose-dependent way) Type 1 Diabetes The pancreas produces little to no insulin Insulin must be given externally There is no reserve safety net In Type 1 diabetes, insulin is not just for glucose control it is a critical anti-ketogenic hormone

A pivotal 2007 study published in the Journal of Physiology and Pharmacology examined rats with experimentally induced esophagitis and sphincter failure

Most only stock single-use 10mL vials of sterile water, which lack the required preservative

MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations

Depending on the individual's condition and lifestyle, the effects can last several days