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Smaller, less rich meals , the most common way to avoid nausea and reflux after a dose increase

The Guidelines are not intended as a substitute for the advice or professional judgment of a health care professional, nor are they intended to be the only approach to the management of clinical problem

doi: 10.2337/diab.38.7.902

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Although its efficacy is lower than methotrexate and cyclosporine, apremilasts favorable safety profile, particularly its low hepatotoxicity risk, makes it a valuable option for patients who require long-term systemic therapy and cannot tolerate immunosuppressants (Papp et al