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Studies have shown that this epithelial damage is in part due to the inability to mitigate reactive oxygen species (ROS)

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393 Direct mitophagy enhancers include urolithin A, which induces mitophagy and improves mitochondrial function in AD and PD models, 394 and kinetin and its analog MTK458, which stabilize PINK1 and enhance Parkin-mediated mitophagy in PD models