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When skeletal muscle is hypoperfused, metabolites accumulate and trigger muscle metaboreflex activation (MMA) (345), further promoting vasoconstriction in skeletal muscle
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Although the liver produces it, every cell can produce glutathione
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it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 50,51,52
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