doi: 10.1007/s10534-025-00745-y 39 AslamTAkhtarBSharifAAnjumFAliSFatimaSAet al
In addition, ferroptosis also changes the inflammatory phenotype in macrophages (Ouyang et al., 2021), which promotes macrophage polarization and then aggravates inflammation (Yu et al., 2021)
Defense Dihexa has been studied for pathways involved in protecting neurons from oxidative stress, inflammation, and age-related cognitive decline
Based on the current evidence, we propose that the iron-overloaded, ROS-prone milieu of EMS renders EESCs susceptible to Erastin-triggered, multi-pathway regulated cell death that integrates ferroptosis with necroptotic and pyroptotic signaling, while ferritin handling and mitophagy act as key modulators of susceptibility
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