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Alcoholic liver disease: Chronic alcohol consumption severely depletes hepatic glutathione through multiple mechanisms: increased ROS production during ethanol metabolism, reduced cysteine availability, and impaired mitochondrial glutathione transport

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Vigilance is essential, particularly in women undergoing therapy beyond five years

[1] This reflux could theoretically result in a bitter or metallic taste in the mouth, particularly when lying down or after meals, though this connection requires further study

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