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Moreover, evidence supporting EGCGs neuroprotective effects via BBB-mediated anti-neuroinflammation and reduction of oxidative stress includes: (i) EGCG enhances dopamine neuron activity in the gut, decreases serotonin levels in the colon, and increases hippocampal 5-hydroxytryptamine levels by enhancing intestinal permeability (215217)

Mice experiments were performed in accordance with the guidelines of the Declaration of Helsinki and the local research ethics committee, as described in protocol number MD-21-16451-5

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There were no significant differences in dietary intake based on participants ethnicity, GLP-1RA usage duration, and education