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The fundamental distinction lies in their mechanism: sulfonylureas provide continuous insulin stimulation (carrying intrinsic hypoglycaemia risk), whilst incretin mimetics offer glucose-responsive action with additional metabolic benefits beyond glycaemic control

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A 10-parameter panel, including not only classical antioxidant tests (FRAC, Trolox, DPPH) but also endogenous antioxidant enzymes and protein degradation, has shown its advantages in stratifying OS status in different HTN degrees (Nuez-Sells et al., 2019)

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