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Additionally, it has been investigated for potential relevance to conditions like skin inflammation, chronic obstructive pulmonary disease, and metastatic colon cancer, owing to its ability to regulate thousands of human genes, with observed effects on resetting DNA expression patterns

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Glutathione ethyl and monoethyl esters are another class of GSH prodrugs that enhance cellular uptake via ester bond-facilitated membrane permeation

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The first GMF was created in 1994, and since then, the use of GMFs has grown rapidly