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On the reverse side, researchers found GLP-1 use was associated with an increased risk of gastrointestinal problems, including nausea, vomiting, diarrhea, and, in rare cases, paralysis of the stomach

Unfortunately, GLP-1-MK-801 also induced significant lean body mass loss, but a group of food-restricted animals (restricted to achieve the same weight loss as the treated group) lost even more lean body mass

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Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes

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