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The most common GI side effects reported were [15]: Nausea (44.2%) Diarrhea (31.5%) Vomiting (24.8%) Constipation (23.4%) Dyspepsia (10.3%) Abdominal pain (10.0%) The trial also reported potentially serious side effects that may occur due to the inhibitory effect of GLP-1 on cholecystokinin synthesis and gallbladder motility, which delays gallbladder emptying [56]

Novo Nordisk) and Wegovy (semaglutide

Therefore, if you are taking one tablet per day as typically prescribed for these medications, then brand-name Janumet is less expensive on a per-day treatment basis

The SURMOUNT-5 trial demonstrated superior weight loss with tirzepatide compared to semaglutide at 72 weeks

ScienceDirect, Rossi, Maddalena, et al