Vijverberg HPM, van der Zalm JM, van den Bercken J
The bisbenzyl isoquinoline alkaloids like tetrandrine, derived from Stephania tetrandra, and compounds like oxymatrine and matrine from Sophora flavescens, have demonstrated abilities to reverse multidrug resistance, induce apoptosis, and inhibit proliferation in cancer cells (72)
This suggests that the dimer form has a significantly higher potency in inhibiting GSTP1 compared to the monomer
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