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While angiogenesis in the adult brain is classically considered quiescent under physiological conditions, mounting evidence from pathological contextssuch as stroke, trauma, glioma, and multiple sclerosisdemonstrates that angiogenic reactivation can occur in response to stress or injury (Thomsen et al

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CoQ 10 is synthesized in the inner mitochondrial membrane, but can subsequently traffic to other membrane systems, including the ER and plasma membrane, via vesicular transport or organelle contact sites 28,36

In contrast, genes directly involved in MT synthesis did not exhibit consistent induction (Supplementary Fig