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Fatty acid cycling in the fasting rat

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Oxidation of phosphatidylcholine during reperfusion produces phosphatidylcholine oxide (OxPC), which disrupts mitochondrial biological function and calcium transport and induces ferroptosis, leading to widespread cell death

Iron metabolism and ferroptosis may induce neurological damage through interactions with the central nervous system, gut microbiota, and brain-gut axis, positioning them as potential therapeutic targets for depression (Figure 3)

Microscopy The tissue specimens were immediately fixed in buffered formalin (pH 7.4), for 24 hours, dehydrated, and embedded in paraffin wax