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Plecanatide is recommended by the ACG for overall symptomatic improvement in IBS-C patients

In these models, homozygous mutation of either Prop1 or Pit1 genes cause an abnormal development of the anterior pituitary, which in turn leads to decline in production of GH, thyrotropin (TSH), and prolactin (PRL), with consequent decrease in circulating IGF-I and thyroxine levels (Bartke, 2011)

Use endogenous NADPH boosters like amla, moringa, curcumin, and shilajit that naturally modulate the redox rhythm