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21 Furthermore, global lactylome profiling of gastrointestinal (GI) cancers, including liver, pancreatic, colorectal, and gastric cancers, further demonstrated that non-histone lactylation exhibits cross-talk with various forms of epigenetic regulation

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The SURPASS and SURMOUNT trials showed tirzepatide producing greater average weight loss than semaglutide over the full treatment period, but both medications produced clinically significant results