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Ferrulli and colleagues ran a randomized, sham-controlled trial of 33 adults with obesity: deep TMS targeting the PFC and insula for five weeks produced significant weight loss that persisted at 12-month follow-up [16]

It contributes to liver detoxification, plays a role in DNA synthesis, and is involved in various metabolic processes

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The MR-Egger method not only allows for testing and estimation of causal effects similar to the IVW method, but also facilitates evaluation of directional pleiotropy through the addition of a parameter, denoted as 0