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Chronic high blood sugar levels initiate a cascade of metabolic abnormalities, which ultimately induce oxidative stress and inflammation, exacerbating nerve injury through excessive production of reactive oxygen species (ROS) and promoting neuronal apoptosis

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The compound progressed through Phase 2 trials under ConjuChem in the mid-2000s for indications including HIV-associated lipodystrophy, but did not advance to a marketed therapeutic in any major jurisdiction

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