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Semaglutide works by mimicking GLP-1, which: Slows digestion, helping you feel full for longer Reduces appetite, so you naturally consume fewer calories Stimulates insulin production after eating, helping to lower blood sugar May lower blood pressure and support better cardiovascular health When combined with lifestyle changes like a healthy diet and regular exercise, once-weekly semaglutide injection can lead to significant reductions in body weight and improvements in overall health

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J Pharmacol Exp Ther 245:171177 [PubMed] [Google Scholar] Balschun D, Moechars D, Callaerts-Vegh Z, Vermaercke B, Van Acker N, Andries L, DHooge R

Later, it becomes part of the mitochondrial sheath around the flagellum, which helps sperm move properly [3]

Semaglutide itself is not listed as a direct cause of joint pain in clinical trial data