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ONOOH may also react with GSH and other thiol residues to form S-nitrosothiols such as nitrosoglutathione (GSNO), a beneficial endogenous bronchodilator (261) that may function as an important signaling mechanism in the presence of nitrosative stress (97, 105, 134)

doi: 10.1016/S0009-2797(97)00151-8

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Prenatal administration of IGF-1 in pregnant wild type (WT) mice results in increased body weight, higher breast density with longer ductal elongation and higher breast stem/progenitor cell populations of prepubescent offspring compared to phosphate buffered saline (PBS) controls [54]