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Neurocutaneous melanosis is characterized by the presence of congenital melanocytic nevi on the skin and melanocytic tumors in the leptomeninges of the central nervous system

The TMA is transported in the portal circulation to the liver, where flavin monooxygenases (FMOs) synthesize trimethylamine-N-oxidase (TMAO) from TMA [38]

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The most frequently reported issues are gastrointestinal, such as nausea, vomiting, diarrhea, and constipation

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