The duration of semaglutide treatment varies, but most patients remain on the medication long-term since discontinuation typically leads to weight regain
This is especially relevant for GLP-1 users who report feeling like the stool is right there but will not come out, or who experience excessive straining despite having soft stool
Even though Semaglutide is powerful and changes how the body handles food and sugar, it is not the only factor that can affect the way urine smells
The SUSTAIN-6 trial , published in the New England Journal of Medicine in 2016, found that participants taking semaglutide had a higher rate of diabetic retinopathy complications compared to placebo (3.0% versus 1.8%)
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