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The pattern is consistent with the Pei 2024 meta-analysis which found cumulative benefits from repeated microneedling sessions

A recent study including spontaneously hypertensive rats and controls (WKY) reported that UA therapy (16 mg/kg) induced Kruppel-like factor 2 (KLF2) expression, lowered vascular endothelial growth factor (VEGF)-A levels, reduced BBB leakage, and improved endothelial cell barrier integrity [194, 196]

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The feeding medium was continuously added into the bioreactor to obtain a constant specific growth rate (0.25 0.02 h 1 ) after the initial glucose in the medium was completely consumed

Chen S, Pan L, Liu S, Pan L, Li X, Wang B (2021) Recombinant expression and surface display of a zearalenone lactonohydrolase from Trichoderma aggressivum in Escherichia coli