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FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

A., Payne, N., Tortorelli, S., Matern, D., Rinaldo, P., Gavrilov, D., Melan, M., He, M., Steinberg, S

It also positively affects glycated hemoglobin, fasting plasma glucose, and lipid profiles

GLP-1RAs may ultimately provide an effective adjunct to lifestyle modifications, improving outcomes for patients with MASLD

These effects contribute to reducing food intake and weight loss, and are of great significance for controlling blood sugar and improving metabolic status