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It is a potentially disabling disease because delayed or insufficient treatment can cause lasting physical damage and disability 3

Pipeline and Emerging Drug Innovations Pipeline developments of GLP-1 analogues are aimed at better treatment options for individuals suffering from diabetes and obesity

It also restores melatonin secretion and normalizes circadian biology

It works through GLP-1 receptor agonism, affecting insulin secretion and appetite signaling, not urinary glucose levels

While patients in frail experienced higher incidence of genital infections when they received SGLT2 inhibitors than those receiving DPP-4 inhibitors, no increases in the incidence of hypoglycemia, ketoacidosis, lower limb amputation and fractures were observed regardless of the frail status in a cohort study of 744,310 patients with type 2 diabetes aged 65 years or older [10]