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In the area of antihepatic fibrosis, ISL could inhibit Annexin A2 expression and block the sphingosine kinases/sphingosine-1-phosphate/IL-17 signaling pathway (Liu et al., 2023), yet, QE decreased hepatic mRNA levels of SphK1 and NLRP3 (Salama et al., 2024)

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These simple adjustments resolve most discomfort without stopping treatment