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Date : DMF Number : 34979 Submission : 2020-08-08 Status : Active Type : II Certificate Number : CEP 2023-075 - Rev 03 Issue Date : 2025-04-25 Type : Chemical Substance Number : 3059 Status : Valid Date of Issue : 2025-09-24 Valid Till : 2028-07-07 Written Confirmation Number : WC-0165 Address of the Firm : NDC Package Code : 52119-017 Start Marketing Date : 2019-07-01 End Marketing Date : 2026-12-31 Dosage Form (Strength) : POWDER (1kg/kg) Marketing Category : BULK INGREDIENT Registrant Name : Daeshin Muyak Co., Ltd

In patient CAS-C, mutations in CTNNB1 , which is linked to melanoma metastasis 19,25 , were found exclusively in brain metastases at residues P44 and S45, both of which regulate beta-catenin 26