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Genetic variants of the six endogenous and five exogenous antioxidants were extracted from the most recent GWAS

It does not bind classical retinoic acid receptors (RARs) the way retinoids do, which is why it carries none of retinol's photosensitivity or purging risk

Shaikh A, Ahmad F, Teoh SL et al (2025) Neurotrophic factor alpha 1 gene therapy in Alzheimers disease: scope and advancements

Because DSIP is a small peptide that acts on the central nervous system and is degraded relatively quickly in plasma (for example, one study reported a half-life of ~78 minutes in human plasma)

It appears that an active transport mechanism concentrates OTA in the kidney, which results in the toxicity of OTA [77,78]