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- Participate in signalling pathways involved in tissue adaptation

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visceral fat fell about 40%. After withdrawal, insulin resistance returned in proportion to regained weight. Maintaining some weight loss did not preserve the full metabolic benefit when substantial regain occurred

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Targeting M2phenotypic TAMs reduces the polarization of macrophages toward the M2 phenotype and raises the amount of M1-TAMs, which in turn strengthens the anti-tumor immune microenvironment (38)