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Initial burning or stinging upon application typically improves with continued use

Food and Drug Administration (FDA) approved dose-adjusted DOAC regimens for stroke prevention

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It must be distinguished between a limited EP damage with relatively stable fragments, closed fracture lines or small defects, which result in no or a limited loss of nucleus tissue (injury type B2), from large defect with a virtual complete loss of NP tissue into the vertebral bone (type B3)